Thouless, Kohmoto, Nightingale and den Nijs in 1982 wrote a landmark paper relating the Hall conductivity to the Chern number (also now known as the TKNN invariant).
It is well-known that the Quantized Hall Effect (QHE) is an extremely robust phenomenon of topological origin (pdf!). One can think of the Hall conductivity as measuring the total Chern number of the occupied Landau levels. What baffles me about the TKNN result is that despite the robustness and topological character of the QHE, the authors are able to use linear response theory.
This must mean that second and higher order responses must somehow be exponentially suppressed and that the response is perfectly linear. I have not come across a proof of this in the literature, though it may very well be an (boneheaded!) oversight on my part. This line of questioning also applies to the Quantum Spin Hall Effect and the Quantum Anomalous Hall Effect.