Research Topics and the LAQ Method

As a scientific researcher, the toughest part of the job is to come up with good scientific questions. A large part of my time is spent looking for such questions and every once in a while, I happen upon a topic that is worth spending the time to investigate further. The most common method of generating such questions is to come up with a lot of them and then sift through the list to find some that are worth pursuing.

One of the main criteria I use for selecting such questions/problems is what I refer to as the “largest answerable question” or LAQ method. Because the lifetime of a researcher is limited by the human lifespan, it is important to try to answer the largest answerable questions that fall within the window of your ability. Hence, this selection process is actually tied in with one’s self-confidence and actually takes a fair amount of introspection. I imagine the LAQ method looking a little bit like this:

Image result for broad to specific triangle

One starts by asking some really general questions about some scientific topic which eventually proceeds to a more specific, answerable, concrete question. If the question is answerable, it usually will have ramifications that will be broadly felt by many in the community.

I imagine that most readers of this blog will have no trouble coming up with examples of success stories where scientists employed the LAQ method. Just about every famous scientist you can think of has probably, at least to some extent, used this method fruitfully. However, there are counterexamples as well, where important questions are asked by one scientist, but is answered by others.

I am almost done reading Erwin Schrodinger’s book What is Life?, which was written in 1943. In it, Schrodinger asks deep questions about genetics and attempts to put physical constraints on information-carrying molecules (DNA was not known at the time to be the site of genetic information). It is an entertaining read in two regards. Firstly, Schrodinger, at the time of writing, introduces to physicists some of the most pertinent and probing questions in genetics. The book was, after all, one that was read by both Watson and Crick before they set about discovering the structure of DNA. Secondly, and more interestingly, Schrodinger gets almost everything he tries to answer wrong! For instance, he suggests that quantum mechanics may play a role in causing a mutation of certain genes. This is not to say that his reasoning was not sound, but at the time of writing, there were just not enough experimental constraints on some of the assumptions he made.

Nonetheless, I applaud Schrodinger for writing the book and exposing his ignorance. Even though he was not able to answer many of the questions himself, he was an inspiration to many others who eventually were able to shed light on many of the questions posed in the book. Here is an example where the LAQ method fails, but still pushes science forward in a tangible way.

What are your strategies with coming up with good research questions? I have to admit that while the LAQ method is useful, I sometimes pursue problems purely because I find them stunning and no other reason is needed!


3 responses to “Research Topics and the LAQ Method

  1. In experimental science, what often happens is that people design an experiment to answer certain questions, but instead find something else unexpected, which turns out to be the more interesting question to answer.


  2. AZ , I entirely agree with you. Quasicrystals work of Dan Schectmann which won the Nobel Prize for him is a wonderful example. The great Linus Pauling did not agree and there were some interesting letters exchanged between Dan S and Pauling. Pauling was wrong and Dan S was right. This is the reason exptl work takes time esp if you get something unexpeced. If you are beginner acdemic and get something new like Dan S, you will not be able to chase your dream like Dan S because you are expected to do what you write in the proposal for funds.


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